What kind of vehicle are we talking about? Sounds like a 4WD truck of some sort. And yes, the driveshaft(s) need to be pulled. From the axle ends at least. The downside is, if you remove them completely, there's a good chance the fluid will leak at the trans. Unbolt them from the axles, then tie them up with some strong wire.
Or get the trailer. It's a lot easier.
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